High-intensity interval training is superior to moderate intensity training on aerobic capacity in rats: Impact on hippocampal plasticity markers

The use of endurance regimens could be improved by defining their respective effectiveness on aerobic fitness and brain health that remains controversial. We aimed at comparing work-matched high-intensity interval training (HIIT) with moderate-intensity continuous (MICT) performance muscular plasticity markers in healthy rats. Cognitive functions were also investigated following the 8-week training. Rats performed incremental exercise test behavioural tests before after day 1 (D1), D15, D29 D57. Key cerebral assessed Western blot quantitative polymerase chain reaction to provide information function related angiogenesis, metabolism neurotrophin activity D59. Muscular protein levels involved angiogenesis measured both triceps brachii soleus muscles. HIIT induced superior improvement compared MICT, as indicated enhancement speed associated lactate threshold (SLT) maximal (Smax). In muscle, upregulated well myokines neuroplasticity. Moreover, key increased hippocampus 8 weeks HIIT, without improving cognitive functions. These findings might contribute define physical guidelines for maintaining highlighting promising role when using SLT distinguishing low running from high speed. Further studies are required confirm these effects exploring synaptic neurogenesis mechanisms intensity is standardized individualized.